MOTS-c

Mitochondrially encoded. 16 amino acids.

16 amino acids, encoded in the mitochondrial 12S rRNA gene
Substance class: mitochondrially encoded peptide (MDP)
Research field: cellular energy homeostasis, AMPK axis

Price per vial

65,00 €

incl. 19% VAT
· Shipping

Quantity

3 vials 3% off, 5 vials 5%, 10 vials 10% — pro rata in between

In preparationShips from Germany

Shipping

Free with code

DHL

Payment

Bank transfer in advance

Account

Not required

GENOME

16 amino acids, encoded in the mitochondrial 12S rRNA gene. Research into cellular energy homeostasis.

Research field

What this is.

MOTS-c belongs to the class of mitochondrially encoded peptides (MDPs). Its open reading frame lies within the mitochondrial 12S rRNA gene, and the peptide comprises 16 amino acids. In preclinical research, MOTS-c is examined in the context of cellular energy homeostasis; described in this connection is an intracellular pathway via the folate-methionine cycle and the AMPK signalling axis coupled to it. A classical membrane receptor has not been identified to date. Further work addresses the translocation of the peptide into the cell nucleus under metabolic stress and its interaction with stress-dependent transcription factors. The material is intended as a reference and research substance for in vitro and preclinical work.

Ageing researchMitochondrially encoded peptideEnergy homeostasisAMPK signalling axisPreclinical research

Specification

Data, not adjectives.

Scientific designation: MOTS-c (mitochondrial open reading frame of the 12S rRNA-c)
Sequence: MRWQEMGYIFYPRKLR (16 aa)
Molecular formula: C101H152N28O22S2
Molecular mass: 2174.6 g/mol
CAS number: 1627580-64-6
Form / packaging: Lyophilisate, 10 mg per vial

Storage

Store the lyophilisate dry, protected from light and at 2–8 °C; for longer storage at −20 °C. Over the shipping period the lyophilisate is stable at ambient temperature, and shipping takes place without a cold chain with short transit times. Avoid repeated temperature changes and document the storage conditions for each batch.

Handling in the lab

Laboratory handling: check the vial for damage on receipt and record the batch, date of receipt and storage location. Let the vial come to room temperature while still closed before opening, so that no condensate forms. Observe general laboratory hygiene, minimise light exposure and repeated temperature changes, and keep continuous records of stock and storage conditions. We do not provide information on preparation or application.

From the lab to you

Every batch takes the same route.

Four steps, none of them optional.

Synthese

Festphasensynthese, anschließend Aufreinigung.

Analyse

Reinheitsbestimmung im Labor.

Identität

Massenspektrometrische Bestätigung der Molmasse.

Charge

Chargennummer auf Etikett, Dokumentation im Haus.

01
Synthese
Festphasensynthese, anschließend Aufreinigung.
02
Analyse
Reinheitsbestimmung im Labor.
03
Identität
Massenspektrometrische Bestätigung der Molmasse.
04
Charge
Chargennummer auf Etikett, Dokumentation im Haus.

Common questions

MOTS-c

A peptide consisting of 16 amino acids whose open reading frame lies within the mitochondrial 12S rRNA gene. It therefore belongs to the class of mitochondrially encoded peptides (MDPs). Sequence: MRWQEMGYIFYPRKLR.

In preclinical research on cellular energy homeostasis. Described are an intracellular pathway via the folate-methionine cycle and the AMPK signalling axis, as well as a translocation into the cell nucleus under metabolic stress.

No. No classical membrane receptor is established in the literature as a target structure for MOTS-c. The described effects are attributed to intracellular signalling pathways. The literature does not go further than this.

In preparation — release follows completion of testing. MOTS-c is currently not available to order. We do not name a date in advance; you can sign up to be notified.

Sold exclusively to persons aged 18 or over for use in laboratory, educational and research settings. No supply takes place for application to humans or animals.

Legal notice

Research chemical for laboratory and research purposes only. Not for human or animal consumption, not for application to humans or animals, not a medicinal product, not a food and not a cosmetic. No dosage, preparation or application recommendations are given and no medical effects are claimed. Sold exclusively to persons aged 18 or over for use in laboratory, educational and research settings.